
Misophonia
Overview
Misophonia is a condition in which specific sensory sensations lead to a strong physical and emotional response. The stimuli causing the response are often referred to as “triggers,” including the sound of people eating, nasal noises like sniffling, and sounds associated with fidgeting like clicking a pen. Exposure to triggers causes the misophonia sufferer to experience a stereotyped physical and emotional response, which includes an increased heart rate, sweating, and activation of stress or anger response. People describe feeling intense anxiety, rage, fear, or the desire to flee.
Philanthropic capital can play a pivotal role in biomedical research, especially in emerging scientific disciplines like misophonia. Donors’ funding can support pilot studies needed to develop an evidence base that will attract additional research grants from larger grant programs. Since 2018, Milken Institute Philanthropy has been working in concert with the Misophonia Research Fund to solicit and fund scientific research aimed at advancing research and alleviating the hardship misophonia causes. To date, the Fund has awarded more than $12 million to support key research with a high potential to yield impactful results. Read more about this partnership here.
Misophonia Research Fund
The Misophonia Research Fund actively solicits misophonia research proposals annually. Each Fall, a Request for Proposals is released describing proposal parameters and soliciting research submissions on an open, global scale. MRF utilizes a two-step process – first requiring a Letter of Intent, then a Full Proposal – to effectively narrow the proposal pool to research ideas yielding impactful results.
Milken Institute Philanthropy conducts a rigorous review process that enlists independent experts to evaluate the promise of each proposal and develops funding recommendations based upon review feedback and overarching program goals.
Program Timeline

Funded Research
Since 2019, Milken Institute Philanthropy has been working in concert with the Misophonia Research Fund to solicit and fund 26 scientific grants worth over $12 million aimed at advancing research and alleviating the hardship misophonia causes. These grants typically span two years of research and may be led by a lead researcher or a postdoctoral scholar.
Annual Research Meeting
Each year, the Misophonia Research Fund convenes all funded researchers for an Annual Meeting of MRF Funded Investigators. This meeting promotes the sharing of research and development of collaborations across institutions that would otherwise go untapped.
This meeting also brings together the program’s Scientific Advisory Board to set strategic directions for the Fund, and acts as a forum to identify and develop new initiatives designed to propel the field forward by leveraging the unique strengths of philanthropic funding.
Consensus Definition
In late 2020, The REAM Foundation and Milken Institute Philanthropy partnered to bring consensus to an otherwise fragmented field through the Delphi Method, a rigorous paradigm that brings experts together to systematically achieve a working definition of a condition.
This paper has led to the development of a unique journal issue around misophonia, released in 2022.
Misophonia
Related Work
2023 Request for Proposals: Misophonia Research Fund
The Misophonia Research Fund (MRF) and the Milken Institute have partnered for the past four years to advance a world where misophonia is scientifically understood and effective treatments are available to help anyone who lives with this...Read ArticleMisophonia Research Fund Announces New Funding, Releases Fifth Request for Proposals to Advance Understanding of Misophonia
Washington D.C., (October 24, 2022) The Misophonia Research Fund today committed nearly $2.2 million in new grants to scientific investigators who seek to characterize misophonia and develop new therapeutic strategies for those living with...Read ArticleImageChad Clinton
Director, Media RelationsChad Clinton is the director of media relations for the Milken Institute. Hired to this role in August 2021, Clinton develops and executes strategies to amplify the Institute’s core messages by generating coverage of its pillar workstreams, experts, and events.Consensus Definition of Misophonia A Delphi Study
Misophonia was named and described in the early 2000’s (Jastreboff and Jastreboff, 2001, 2002) and has since gained scientific recognition and clinical identification across a wide variety of disciplines (e.g., audiology, neuroscience...Read ReportRequest for Proposals: Misophonia
The Misophonia Research Fund is pleased to release the 2023 Request for Proposals. The General Grant Program RFP is soliciting research proposals that aim to characterize misophonia, develop objective methods to assess misophonia, or...Read ArticleMisophonia - A Giving Smarter Guide
While some sounds can be annoying for most people, for a few, certain sounds like chewing, sniffling, or pen clicking can trigger an intense physical and emotional response. Those with this condition can experience increased heart rate...Read ReportJR
Meet Advisory Board
To learn more about the members of the Misophonia Research Fund Scientific Advisory Board, visit the board page.