Global health security—progress toward a world safe and secure from infectious-disease threats—is a growing priority in the US and globally. Because disease outbreaks, growing resistance to antimicrobial drugs, and other global health threats can take a devastating toll on economies, global health security is not simply a health imperative, but it's also critical to ensuring economic prosperity in a region. What are the emerging issues for infectious-disease threats? How are we tackling these issues and what more can be done? New challenges in global health and the changing nature of partnerships will be explored in this conversation.